Open Access
Regen Med Res
Volume 8, 2020
Article Number 1
Number of page(s) 7
Published online 16 January 2020
  1. Zlotorynski E (2018), Histone methylation boosts liver regeneration. Nat Rev Mol Cell Biol 20, 454–455. [Google Scholar]
  2. Zafarnia S, Mrugalla A, Rix A, Doleschel D, Gremse F, Wolf SD, Buyel JF, Albrecht U, Bode JG, Kiessling F, Lederle W (2019) Non-invasive imaging and modeling of liver regeneration after partial hepatectomy. Front Physiol 10, 904 . [CrossRef] [PubMed] [Google Scholar]
  3. Wang S, Zhang C, Hasson D, Desai A, SenBanerjee S, Magnani E, Ukomadu C, Lujambio A, Bernstein E, Sadler KC (2019) Epigenetic compensation promotes liver regeneration. Dev Cell 50, 43–56.e6 . [CrossRef] [PubMed] [Google Scholar]
  4. Van Haele M, Snoeck J, Roskams T (2019), Human liver regeneration: an etiology dependent process. Int J Mol Sci 20, pii: E2332 . [Google Scholar]
  5. Valizadeh A, Majidinia M, Samadi-Kafil H, Yousefi M, Yousefi B (2019), The roles of signaling pathways in liver repair and regeneration. J Cell Physiol, DOI: . [Google Scholar]
  6. Li N, Kong M, Zeng S, Hao C, Li M, Li L, Xu Z, Zhu M, Xu Y (2019), Brahma related gene 1 (Brg1) contributes to liver regeneration by epigenetically activating the Wnt/β-catenin pathway in mice. FASEB J 33, 327–338 . [CrossRef] [PubMed] [Google Scholar]
  7. Pepe-Mooney BJ, Dill MT, Alemany A, Ordovas-Montanes J, Matsushita Y, Rao A, Sen A, Miyazaki M, Anakk S, Dawson PA, Ono N, Shalek AK, van Oudenaarden A, Camargo FD (2019) Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration. Cell Stem Cell 25, 23–38.e8 . [Google Scholar]
  8. Preziosi M, Okabe H, Poddar M, Singh S, Monga SP (2018) Endothelial Wnts regulate β-catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt-Wnt situation. Hepatol Commun 2, 845–860 . [CrossRef] [PubMed] [Google Scholar]
  9. Lanthier N, Spahr L (2019) Resident liver progenitor cells: Proofs of their contribution to human liver regeneration. Clin Res Hepatol Gastroenterol 43, 646–648 . [Google Scholar]
  10. Duan JL, Ruan B, Yan XC, Liang L, Song P, Yang ZY, Liu Y, Dou KF, Han H, Wang L (2018) Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice. Hepatology 68, 677–690 . [CrossRef] [PubMed] [Google Scholar]
  11. Ru YX, Dong SX, Zhao SX, et al. (2019), One cell one niche: hematopoietic microenvironments constructed by bone marrow stromal cells with fibroblastic and histiocytic features. Ultrastruct Pathol 43, 117–125 . [CrossRef] [PubMed] [Google Scholar]
  12. Zhai R, Wang Y, Qi L, et al. (2018), Pharmacological mobilization of endogenous bone marrow stem cells promotes liver regeneration after extensive liver resection in rats. Sci Rep 8, 3587 . [CrossRef] [PubMed] [Google Scholar]
  13. Mikael PE, Willard C, Koyee A, et al. (2019), Remodeling of glycosaminoglycans during differentiation of adult human bone mesenchymal stromal cells toward hepatocytes. Stem Cells Dev 28, 278–289 . [CrossRef] [PubMed] [Google Scholar]
  14. Gupta P, Sata TN, Yadav AK, et al. (2019), TGF-β induces liver fibrosis via miRNA-181a-mediated down regulation of augmenter of liver regeneration in hepatic stellate cells. PLoS One 14, e0214534 . [CrossRef] [PubMed] [Google Scholar]
  15. Overi D, Carpino G, Cardinale V, et al. (2018), Contribution of resident stem cells to liver and biliary tree regeneration in human diseases. Int J Mol Sci 19, 2917 . [Google Scholar]
  16. Shi JH, Line PD (2019) Hallmarks of postoperative liver regeneration- an updated insight on the regulatory mechanisms [published online ahead of print, 2019 Nov 29. J Gastroenterol Hepatol, DOI: . [Google Scholar]
  17. Müsch A (2018), From a common progenitor to distinct liver epithelial phenotypes. Curr Opin Cell Biol 54, 18–23 . [CrossRef] [PubMed] [Google Scholar]
  18. Li HM (2017), Comprehensive and in-depth study of traditional Chinese medicine regulation of liver regeneration. Chin J Integr Tradit West Med Liver Dis 17, 129–132 . [Google Scholar]
  19. Li HM (2011), Essence of deficiency syndrome and generate of vitality theory. Chin Arch Tradit Chin Med 29, 2157–2160 . [Google Scholar]
  20. Qian Y (2018), Jieduan Niwan method for chronic severe hepatitis. Beijing J Tradit Chin Med 27, 85–86 . [Google Scholar]
  21. Hu JH, Qian Y, Yao NL, Nie G, Wu QK, Li XD, Gou CY, Yang HS, Li XH (2016) Treatment of chronic severe hepatitis B by Jieduan Niwan method. Chin J Integr Tradit West Liver Dis 20, 200–203 . [Google Scholar]
  22. Wang LF, Li J, Li FY, Zhang XF, Zhang MX, Cao WK, Li Q, Wen XM, Mao DW, Sun KW, Zhou XZ, Tian DY, Guo JC, Yang DG, Li XH, Yang HZ, Wang XB, Zhuo YH, Zhang Q, Li HM, Hu XY, Zhao W, Zhang FC, He LY (2013) A multicentered, randomize-controlled trial of integrative medicine for acute-on-chronic (subacute) liver failure. J Tradit Chin Med 54, 1922–1925 . [Google Scholar]
  23. Dang ZQ, Yang GH, Ma YJ, Zhao CP, Yu JZ, Xi YH, Wang HX (2017) Synergistic effect of multi-ways chinese medication on routine therapy for hepatitis B virus related acute-on-chronic liver failure. J Tradit Chin Med 53, 2109–2111 . [Google Scholar]
  24. Liu HM, Wang XB, Hou YX, Gao FY, Sun FX, Jiang YY, Yang ZY, Du HB, Wang XJ, Zhou GQ, Yang YY, Wang RB (2014) Patients with hepatitis B virus related acute-on-chronic liver failure: a randomized controlled clinical study. Chin J Integr Tradit West Med 34, 412–417 . [Google Scholar]
  25. Chen YQ, Mao DW, Tang N, Liu LH, Wang N (2015) Efficacy of modified Yinchen Sini Tang in acute-on-chronic liver failure. Chin J Exp Tradit Med Formulae 21, 163–166 . [Google Scholar]
  26. Huang GY, Mao DW, Long FL, Huang B, Huang ZF, Li DF, Qiu H, Chen C, Zhang RZ, Lv JL, Zeng F (2018) Retention enema with rhubarb decoction in treating hepatic encephalopathy: results from a multi-center clinical trial. Liaoning J Tradit Chin Med 7, 1364–1366 . [Google Scholar]
  27. Hu XY, Zhang Y, Chen G, Zhong S, Fan XJ (2012) A prospective cohort study on the influence of high doses of herbs for clearing heat and resolving stasis on survival rates in patients with hepatitis B-related acute-on-chronic liver failure. J Chin Integr Med 10, 176–185 . [CrossRef] [Google Scholar]
  28. Wu XR, Guo WD, Ma XH (2009) Effect of rhubarb on liver injury and liver regeneration in fulminant hepatic failure. Chin J Hepatol 7, 37–38 . [Google Scholar]
  29. Shi WL, Liu FF, Sun YQ (2015) Thoughts and methods for prevention and treatment of triple factors in the mechanism of hepatitis B-related acute-on-chronic liver failure. J Beijing Univ Tradit Chin Med (Clin Med) 17, 35–37 . [Google Scholar]
  30. Liu CN, Liu XY, Yang J, Wu GQ, Wang HX (2009) The protective effects of artemisiae capillaris on hepatic damage and its mechanism. Lishizhen Med Mater Med Res 20, 2987–2989 . [Google Scholar]
  31. Yang M, Wang WD, Zhang LJ, Liu YX, Ma SX (2018) Experimental research on the effects of nanometer Yin Chen mixture to TN F-α and H GF in the serum of rats with fulminant hepatic failure. J Harbin Med Univ 42, 367–370 . [Google Scholar]
  32. Chen SD, Feng Q, Peng JH, Xu LL, Liu P, Liu C, Hu YY (2009). Research of herba artemisiae scoporiae inhibits the hepatic lipotoxicity. Chin J Chin Mater Med 34, 2373–2378 . [Google Scholar]
  33. Sun T, Chen Y (2010) Advances in research on pharmacological effects of Yinchen. Pharm Clin Chin Mater Med 1, 59–61 . [Google Scholar]
  34. Qi Z, Zheng BZ, Liu JP, Li PY (2016) Advances in studies on biological activities of licorice. Special Wild Economic Animal and Plant Research 38, 71–76. [Google Scholar]
  35. Shen L, Tao YY, Zhao ZM, Liu HL, Liu CH (2015) Screen active ingredient of liquorice via anti-liver sinusoidal endothelial cells hypoxia injury. Chin J Integr Tradit West Med Liver Dis 25, 227–230 . [Google Scholar]
  36. Shin T, Kuboki S, Lentsch AB (2018) Roles of nuclear factor-kappaB in postischemic liver. Hepatol Res 38, 429–440 . [Google Scholar]
  37. Wu J, Zern MA (1999), NF-kappa B, liposomes and pathogenesis of hepatic injury and fibrosis. Front Biosci 4, D520–D527 . [Google Scholar]
  38. Qiu HP, Li XL, Yao HP (2016) Study on the mechanism of SNMT on acute liver injury in mice by NF-κB signaling pathway. Chongqing Med 45, 4211–4213 . [Google Scholar]
  39. Li HM (2009), The scientific connotation of kidney essence. J Tradit Chin Med 50, 1061–1064 . [Google Scholar]
  40. Li H (2012) EMT/MET imbalance and lost marrow to generate liver. Chin J Integr Tradit West Med Liver Dis 21, 385–389 . [Google Scholar]
  41. Li H (2015), Research progress in the essence of marrow. J Hubei Univ Chin Med 17, 100–103 . [Google Scholar]
  42. Li H (2017), Therapeutic principle of “nourishing kidney to produce marrow and generate liver”. Chin Arch Tradit Chin Med 30, 937–940 . [Google Scholar]
  43. Bihari C, Anand L, Rooge S, Kumar D, Saxena P, Shubham S, Sukriti N, Kumar G, Pamecha V, Sharma S, Rastogi A, Kumar A, Sarin SK (2016) Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver. Hepatology 64, 1273–1288 . [CrossRef] [PubMed] [Google Scholar]
  44. Li H, Zhang L, Qiu X, Mei J, Wang P (2011) Study on the mechanism of Zuogui Pill in improving MSG-liver Regeneration-deficiency syndrome of kidney essence and liver blood deficiency in rats. J Hubei Coll Tradit Chin Med 3, 30–33 . [Google Scholar]
  45. Li HM, Yang M, Mei J, Zhang L, Qiu X (2014) The effects of Zuogui Pill on expression of TGF-α, β and their receptors in rats. Chin J Hepatol 12, 307–308 . [Google Scholar]
  46. Li H, Gao X, Yang M, Mei J, Zhang L, Qiu X (2004) Effects of Zuogui Wan on neurocyte apoptosis and downregulation of TGF-beta1 expression in nuclei of acute hypothalamus of monosodium glutamate -liver regeneration rats. World J Gastroenterol 10, 2823–2826 . [CrossRef] [PubMed] [Google Scholar]
  47. Li H, Gao X, Zhou M. Zuogui Pill regulates MSG-liver regeneration-related gene expression in rats. Chinese Journal of Basic Medicine in Traditional Chinese Medicine. 2015; 11: 595–598. [Google Scholar]
  48. Li H, Gao X, Yan X, Ming A, Peng Y, Li J (2005) Study on the effect of Zuogui Pill in promoting bone marrow cells to form hepatic cells. World Chin J Digestol 13, 2818–2822 . [Google Scholar]
  49. Li H, Gao X, Yan X, Ming A, Peng Y (2016) Study on the molecular mechanism of Zuogui Pill in promoting bone marrow cells to form hepatic cells. J Tradit Chin Med 47, 778–780 . [Google Scholar]
  50. Li H, Yan X, Luo J, Li J, Gao X, Ming A, Peng Y (2017) Effect of Zuogui Pill medicated serum on the differentiation of bone marrow mesenchymal stem cells into hepatocytes. J Clin Rehab Tissue Eng Res 11, 5465–5468 . [Google Scholar]
  51. Li H, Gui W, Li J, Gao X, Yan X, Cheng Y (2008) Effect of Zuogui Pill on the liver regeneration related gene signal pathway in female mice with female mice bone marrow transplant. J Clin Rehab Tissue Eng Res 12, 6069–6073 . [Google Scholar]
  52. Gao X, Li H, Yan X (2010) Effects of Zuogui Pill on wnt signal pathway in female mice with male mice bone marrow transplant. Chin J Integr Tradit West Med Liver Dis 20, 29–31 . [Google Scholar]
  53. Li H, Gao X, Yan X (2015) Studies of Zuogui Pill medicated serum pharmacology based on co-culture system of bone marrow stem cells and hepatocytes. J Clin Rehab Tissue Eng Res 14, 3527–3532 . [Google Scholar]
  54. Song H, Li H, Li L, Gao X, Zhao B, Zhang J, Wu Y, Yan X, Xiao L (2013) Effects of Diwuyanggan capsule on liver regeneration of rat with deficiency of kidney essence and liver blood. Chin J Integr Tradit West Med Liver Dis 23, 90–92 . [Google Scholar]
  55. Li H (2013), The basic and clinical application of “tonifying kidney to generate marrow and liver” in the treatment of liver disease. World Sci Technol/Modern Tradit Chin Med Mater 15, 1425–1428 . [Google Scholar]
  56. Li H (2018), Introduction to regenerative traditional Chinese medicine. Chin Arch Tradit Chin Med 26, 2309–2312 . [Google Scholar]
  57. Wu X, Huang B, Feng B (2012) Advances in molecular mechanism of liver regeneration. Chin Med Pharm 2, 64–66 . [Google Scholar]
  58. Zhang AM (2012) Clinical efficacy and mechanism in the treatment of chronic severe hepatitis by heat-clearing, detoxifying and dampness-removing methods. Jiangxi J Tradit Chin Med 43, 23–27 . [Google Scholar]
  59. Gao Y, Chen GM, Liang ZY, Xie YQ (2013) Advances in research on the effects of cytokines on liver fibrosis. Hainan Med J 24, 111–113 . [Google Scholar]
  60. Li Y, Ma SP (2015), A TCM study on correlation between TNF-α, IL-6 and hepatitis B. Clin J Chin Med 7, 146–148 . [Google Scholar]
  61. Parola M, Pinzani M (2019) Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. Mol Aspects Med 65, 37–55 . [CrossRef] [PubMed] [Google Scholar]
  62. Friedman SL (2008), Hepatic fibrosis-overview. Toxicology 254, 120–129 . [CrossRef] [PubMed] [Google Scholar]
  63. Kordes C, Sawitza I, Müller-Marbach A, Ale-Agha N, Keitel V, Klonowski-Stumpe H, Häussinger D (2007) CD133+ hepatic stellate cells are progenitor cells. Biochem Biophys Res Commun 352, 410–417 . [Google Scholar]
  64. Li HM (2015) Prevention and treatment of liver fibrosis by regulating liver regeneration. J Clin Hepatol 31, 992–994 . [Google Scholar]
  65. Shen X, Cheng S, Peng Y, Song H, Li H (2014) Attenuation of early liver fibrosis by herbal compound “Diwu Yanggan” through modulating the balance between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition. BMC Complement Altern Med 14, 418 . [CrossRef] [PubMed] [Google Scholar]
  66. Cheng SS, Shen X, Peng Y, Li HM (2015) Effect of Diwu Yanggan Capsule on EMT/MET of liver tissue in rats with hepatic fibrosis. Lishizhen Med Mater Med Res 26, 826–829 . [Google Scholar]
  67. Shen X, Peng Y, Cheng SS, Li HM (2015) Regulation effect of Diwu Yanggan Capsule on the Hedgehog signal pathway in the liver tissues of fibrotic rats. Chin J Tradit Chin Med Pharm 30, 2955–2957 . [Google Scholar]
  68. Dusabineza AC, Van Hul NK, Abarca-Quinones J, Starkel P, Najimi M, Leclercq IA (2012) Participation of liver progenitor cells in liver regeneration: lack of evidence in the AAF/PH rat model. Lab Investig 92, 72–81 . [CrossRef] [Google Scholar]
  69. Dezső K, Papp V, Bugyik E, Hegyesi H, Sáfrány G, Bödör C, Nagy P, Paku S (2012), Structural analysis of oval-cell-mediated liver regeneration in rats. Hepatology 56, 1457–1467 . [CrossRef] [PubMed] [Google Scholar]
  70. Zhang W, Chen XP, Zhang WG, Zhang F, Xiang S, Dong HH, Zhang L (2009) Hepatic non-parenchymal cells and extracellular matrix participate in oval cell-mediated liver regeneration. World J Gastroenterol 15, 552–560 . [CrossRef] [PubMed] [Google Scholar]
  71. Zhao BB, Li HM, Gao X, Ye ZH, Cheng SS (2015) The herbal compound “diwu yanggan” modulates liver regeneration by affecting the hepatic stem cell microenvironment in 2-acetylaminoflfl uorene/partial hepatectomy rats. Evid Based Complement Alternat Med 2015, 468303 . [Google Scholar]
  72. Li H, Zhang L (2017) Liver regeneration microenvironment of hepatocellular carcinoma for prevention and therapy. Oncotarget 8, 1805–1813 . [PubMed] [Google Scholar]
  73. Li HM (2016), Microcirculation of liver cancer, microenvironment of liver regeneration, and the strategy of Chinese medicine. Chin J Integr Med 22, 163–167 . [CrossRef] [PubMed] [Google Scholar]
  74. Li HM (2015), Construction and application of tertiary prevention program for liver cancer based on “tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment”. Chin J Integr Tradit West Med Liver Dis 25, 369–372 . [Google Scholar]