| Issue |
Regen Med Res
Volume 2, 2014
|
|
|---|---|---|
| Article Number | 3 | |
| Number of page(s) | 10 | |
| DOI | https://doi.org/10.1186/2050-490X-2-3 | |
| Published online | 03 February 2014 | |
Review
Ischemic stroke and repair: current trends in research and tissue engineering treatments
1
Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2
Medical Research Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
* Correspondence: katelinwang@gmail.com
Received: 21 August 2013
Accepted: 24 October 2013
Stroke, the third leading cause of mortality, is usually associated with severe disabilities, high recurrence rate and other poor outcomes. Currently, there are no long-term effective treatments for stroke. Cell and cytokine therapies have been explored previously. However, the therapeutic outcomes are often limited by poor survival of transplanted cells, uncontrolled cell differentiation, ineffective engraftment with host tissues and non-sustained delivery of growth factors. A tissue-engineering approach provides an alternative for treating ischemic stroke. The key design considerations for the tissue engineering approach include: choice of scaffold materials, choice of cells and cytokines and delivery methods. Here, we review current cell and biomaterial based therapies available for ischemic stroke, with a special focus on tissue-engineering strategies for regeneration of stroke-affected neuronal tissue.
Key words: Ischemic stroke / Tissue engineering / Biomaterials / Neuro-protective factors / Cell therapy
© 2014 Wang et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.