Circulating CD34+ hematopoietic stem/progenitor cells paralleled with level of viremia in patients chronically infected with hepatitis B virus

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Table 1

Clinical characteristics of the enrolled subjects.

Parameters	CHB (n = 30)	CHB with ETV (n = 30)	Control (n = 20)	P value
Male/Female	20/10	18/12	14/6
Age (year)	45 ± 8.2	45 ± 12.7	43 ± 8.2	0.351
ALT (IU/L)	237 ± 96.8^*	20 ± 4.2	18.3 ± 3.8	<0.0001
Total bilirubin (mg/dL)	1.75 ± 0.9^*	0.7 ± 0.32	0.6 ± 0.3	<0.0001
INR	1.1 ± 0.2	1,12 ± 0.23	1 ± 0.09	0.108
WBC count (×10³/uL)	6.8 ± 1.7	7.3 ± 2.3	6.9 ± 2	0.923
HBV DNA( log₁₀ copies/mL) (P/N)	8.3 ± 4.5	<LOD (4/26)	ND
HBsAg (positive/negative)	30/0	27/3	ND
HBeAg (positive/negative)	6/24	7/23	ND
Anti-HBe Ab (positive/negative)	24/6	23/7	ND
Prior medication for HBV	0	ETV	0

CHB = Chronic hepatitis B; ETV = Entecavir; ALT = Alanine aminotransferase; INR = International normalized ratio; WBC = White blood cells; LOD = Limit of detection (20 IU/mL); P = Positive; N = Negative; ND = Not determined. Data are expressed as mean ± SD.

Significant deviation from the control as indicated by P value < 0.05.

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