Open Access

Table 1

Clinical characteristics of the enrolled subjects.

Parameters CHB (n = 30) CHB with ETV (n = 30) Control (n = 20) P value
Male/Female 20/10 18/12 14/6  
Age (year) 45 ± 8.2 45 ± 12.7 43 ± 8.2 0.351
ALT (IU/L) 237 ± 96.8* 20 ± 4.2 18.3 ± 3.8 <0.0001
Total bilirubin (mg/dL) 1.75 ± 0.9* 0.7 ± 0.32 0.6 ± 0.3 <0.0001
INR 1.1 ± 0.2 1,12 ± 0.23 1 ± 0.09 0.108
WBC count (×103/uL) 6.8 ± 1.7 7.3 ± 2.3 6.9 ± 2 0.923
HBV DNA( log10 copies/mL) (P/N) 8.3 ± 4.5 <LOD (4/26) ND  
HBsAg (positive/negative) 30/0 27/3 ND  
HBeAg (positive/negative) 6/24 7/23 ND  
Anti-HBe Ab (positive/negative) 24/6 23/7 ND  
Prior medication for HBV 0 ETV 0  

CHB = Chronic hepatitis B; ETV = Entecavir; ALT = Alanine aminotransferase; INR = International normalized ratio; WBC = White blood cells; LOD = Limit of detection (20 IU/mL); P = Positive; N = Negative; ND = Not determined. Data are expressed as mean ± SD.

*

Significant deviation from the control as indicated by P value < 0.05.

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