| Issue |
Regen Med Res
Volume 3, 2015
|
|
|---|---|---|
| Article Number | 2 | |
| Number of page(s) | 7 | |
| DOI | https://doi.org/10.1186/s40340-015-0011-8 | |
| Published online | 02 December 2015 | |
Research
Chronic stress does not impair liver regeneration in rats
1
Department of Surgical Gastroenterology L, Aarhus University Hospital, 8000 Aarhus C, Denmark
2
Institute of Clinical Medicine – Translational Neuropsychiatry Unit, Aarhus University Hospital, Aarhus, Denmark
* Correspondence: kasperjarlheltandersen@gmail.com
Received: 4 September 2015
Accepted: 25 November 2015
Background: Although wound healing is a simple regenerative process that is critical after surgery, it has been shown to be impaired under psychological stress. The liver has a unique capacity to regenerate through highly complex mechanisms. The aim of this study was to investigate the effects of chronic stress, which may induce a depression-like state, on the complex process of liver regeneration in rats.
Methods: Twenty rats were included in this study. The animals received either a standard housing protocol or were subjected to a Chronic Mild Stress (CMS) stress paradigm. All rats underwent a 70 % partial hepatectomy (PHx). The animals were evaluated on postoperative day 2 or 4. Blood samples were collected to examine circulating markers of inflammation and liver cell damage. Additionally, liver tissues were sampled to evaluate liver weight and regeneration rate.
Result: None of the animals died during the study. There were no differences between in body weight, liver weight, liver regeneration rate or biochemical markers at any time during the study.
Conclusion: The results of this study indicate that stress and the induction of depression-like state do not affect the process of liver regeneration after 70 % hepatectomy in rats.
Key words: Liver regeneration / Surgery / Chronic stress / Depression / Rats
© 2015 Andersen et al.
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