Open Access
Table 2
Characteristics of patients included in the study and wound evolution before and after CACIPLIQ20 treatment. M, male; F, female; F, fibrin; G, granulation tissue; SR, surface reduction; RF, right foot.
| Case # | Age, years, sex | Ulcer location | Ulcer duration | Ulcer size at baseline (cm2) | Aspect at baseline | Appearance after 4 weeks | % SR after 2 weeks | % SR after 4 weeks | % SR after 8 weeks | Healing after 12 weeks | Commments | Follow up (months) | Alive at last follow up |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 87M | Foot, medial aspect | 12 | 0.5 | 100%F | 90%G 10%F | 0% | 0% | 49% | Stopped | Left the study after 8 weeks, AHT | Lost to follow up | |
| 2 | 86F | Foot, medial edge | 6 | 0.45 | 100%F | 20%F 80%G | 44% | 44% | 80% | Healed | Hypertension, myocardial infarction, AHT | 24 | Yes |
| 2 | 86F | Heel | 6 | 1.05 | 30%F 70%G | Healed | 100% | 100% | 100% | Healed | Yes | ||
| 3 | 85F | Left, medial aspect | 10 | 9.1 | 10%F 90%G | 90%G 10%F | 0% | 0% | 23% | Stopped | Bacterial infection between 4 and 8 weeks HTA healed later | 24 | Yes |
| 4 | 83M | Foot, sole | 2 | 5.6 | 30%F 70%G | 100%G | 4% | 36% | 49% | Not healed | Renal dialysis, died months after study completion from unrelated causes, HTA | 16 | Yes |
| 5 | 88M | Big toe, lateral aspect | >18 | 0.99 | 100%F | 70%F 30%G | 19% | 0% | 0% | Not healed | Died from cachexia, HTA, smoker | 2 | No |
| 6 | 93F | Lateral malleolus | 4 | 73.8 | 20%F 80%G | 95%G | 13% | 13% | 27% | Healed other slowly healing ulcers, HTA | Lost to follow up | ||
| 7 | 74M | Foot, lateral edge | >12 | 2.4 | 100%G | 100%G | 37% | 62% | 100% | Healed | 24 | Yes | |
| 8 | 63M | Heel | 7 | 0.7 | 20%F 80%G | 100%G | 14% | 29% | −50% | Not healed | Bacterial infection, bladder carcinoma, HTA | 24 | Yes |
| 9 | 62M | Stump ulcer | 1 | 49 | 20%F | 100%G | 11% | 46% | 100% | Healed | Diabetes | 12 | Yes |
| 9 | 62M | 2 weeks after femoral amputation | 15 | 80%G | 0% | 78% | 100% | Healed | 12 | Yes | |||
| 10 | 89F | >12 | 0.6 | 50%F 50%G | 100%G | 0% | 40% | 100% | Healed | HTA | Lost to follow up | ||
| 11 | 78M | 1 | 41.2 | 90%G | 0% | 24% | 56% | Not healed | 24 | Yes | |||
| 12 | 62M | 2 | 24 | 30% SR stopped the treatment | 20% | 13% | NA | Not healed | Amputation of 4 toes 3 months later then healed with CACIPLIQ20® (outof the study), HTA, diabetes, smoker | 24 | Yes | ||
| Total | 1 healed, remain 13 | 5 healed remain 12 | 7 healed remain 7 | 8 alive |