Case 2 (a) 65 year old patient with an ischemic, diabetic, neuropathic foot ulcer that had not shown improvement for 6 months before treatment, presenting with a necrotic lesion (black arrows) on the ligament and no granulation tissue (b) After 2 weeks of treatment with OTR4120, the necrotic zone diminished and granulation tissue formed, allowing the patient to avoid amputation and to be eligible for a skin graft.